3D microstructures for organ-on-a-chip,without equipment

FiberCyte rapidly generates cell-lined channel networks inside 3D hydrogels, replacing complex bioprinting with a simple, temperature-triggered sacrificial template.

The problem

Building complex 3D tissue models is slow, expensive, and limited in resolution. Bioprinting, today's go-to for microvascular networks and nerve guides, struggles the moment living cells are involved, demanding extensive optimization and costly equipment.

Without a simpler way to form perfusable, cell-lined channels inside hydrogels, organ-on-a-chip models stay too simple to faithfully replicate real human tissue.

The invention

FiberCyte is built on a patented temperature-responsive polymer that forms 3D structures inside hydrogels, with no bioprinter required.

Cells can grow directly on the template before embedding, or be seeded later. A simple cool-down to 4 °C dissolves the polymer within minutes, leaving cell-lined, perfusable channels behind.

No toxic solvents. No cell damage. No expensive equipment. Plug and play.

How it works

Three steps, no specialized hardware, no post-seeding or pre-treatment.

Step 01

Insert the template

An OXA template is added to the chip. Cells can optionally be grown and attached to its surface beforehand, or seeded later.

Bare OXA template tube
Template only
OXA template with cells grown on its surface
With cells attached
Step 02

Embed in hydrogel

Hydrogel containing your cells is cast around the template and crosslinked, locking the geometry in place.

Hydrogel with cells cast around the template and crosslinked
Step 03

Cool to 4 °C

A short cool-down in the fridge dissolves the template in minutes, leaving a clean, cell-lined, perfusable channel.

Template dissolves in minutes, leaving a perfusable channel

Key advantages

Designed to drop into existing workflows and reach the resolution real tissue requires.

5+
Hydrogels

Compatible across a broad range of matrices.

0
Equipment

Plug & play. No bioprinter or specialized hardware.

3
Steps

No post-seeding or pre-treatment required.

~10 µm
Resolution

Fine enough to replicate capillaries and axonal guides.

Validated use cases

Demonstrated across multiple physiologically relevant tissue models.

Blood–brain barrier

Endothelial cells and astrocytes arranged in physiologically correct geometry.

Perfusable microvasculature

Endothelial-lined channels with supporting stromal cells.

Nerve outgrowth

Schwann-cell conduits guiding human neuron axon growth across channels.

Who it's for

From drug screening to disease modeling to next-generation chip design.

Pharma & biotech

Drug screening and preclinical testing with more predictive human models, reducing reliance on animal studies.

Academic researchers

Disease modeling, tissue microenvironment studies, and tissue innervation in a reproducible format.

Organ-on-chip manufacturers

Integrate with and improve current chips, enabling rich hydrogel architectures.

Looking for early adopters

Let's build better tissue models together

We're currently accepting pilot collaborations with pharma, biotech, academic, and organ-on-chip teams.

Get in touch